Jose Mourinho's team enjoyed a good group campaign, recording five wins from their six group games.
Which teams are through to the Champions League Round of 16 stage?
CSKA drop into the Europa League, while Basel reached the last 16 for the third time this decade, the Swiss champions beating Benfica 2-0 in Lisbon with goals from Mohamed Elyounoussi and Dimitri Oberlin.
The versatile defender, who only returned to action a fortnight ago after seven months out following surgery on a serious cruciate ligament injury, was omitted from the matchday squad entirely on Tuesday having been forced to play the full 90 minutes in successive fixtures due to the absence of Bailly and Jones.
Not even Alan Dzagoev's controversial opener had the Old Trafford faithful concerned as only a record seven-goal defeat would deny United, who turned things around through quick-fire Romelu Lukaku and Marcus Rashford goals to triumph 2-1.
Now that the group stage is over, here's everything you need to know for the Round of 16.
Elsewhere, Roma recorded a 1-0 win over Qarabag at the Stadio Olimpico.
So, how did the names linked with a Premier League move perform in the Champions League tonight?
"The truth is Eric Bailly no chance for the weekend, Phil Jones a chance, Fellaini a chance, Zlatan a big chance and Matic is injured but will play for sure".
Paco Alcacer's near post flick and Jeremy Mathieu's own goal helped Barca ease past Sporting and ensured they won Group D, while Juan Cuadrado and Federico Bernardeschi wrapped things up for Juventus against Olympiacos.
There are still some issues to be resolved in Wednesday night's Champions League games.
No English club can play another in the next round of the competition.
In Group H, Tottenham have already finished top, with Real Madrid second place three points behind.
Atletico Madrid, finalists in two of the past four years, crashed out of Group C despite Saul Niguez heading home the opening goal at Chelsea on 56 minutes.
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