The Swiss side finished with 10 men after defender Mohamed Ali Camara was sent off for a second caution with 12 minutes left.
Madrid were without injured trio Gareth Bale, Isco and Marcelo for their trip to Russia, while Sergio Ramos was rested and Luka Modric only among the subs. The two clubs drew 1-1 in Moscow, with Real easily winning 4-1 in Madrid. The Germans' idea was to send it back to Varane but it was under hit and intercepted by Vlasic who took one touch before sending it past Keylor Navas.
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Champions League holders Real Madrid will have to work around a string of injuries to key players in a tough match against CSKA Moscow, manager Julen Lopetegui said on Monday. CSKA's defense and keeper Igor Akinfeev will be tested by Madrid's offensive firepower. Casemiro hit the post in the 28th minute with a speculative shot, Karim Benzema headed onto the bar in the 40th, and Mariano Diaz headed onto the post late on.
Nikola Vlasic scored after 65 seconds to earn CSKA a memorable Group G win at the Luzhniki Stadium on Tuesday, with Lopetegui left to ponder his team's problems in front of goal.
The pressure on Jose Mourinho is increasing.
"We have lacked fortune, we have tried and from distance, in the centre, through crossing balls".
United are up against Juventus in their next two Champions League games, as they will host the Italian giants on October 23 before the reverse fixture in Turin on November 7.
Sergio Aguero's equaliser seven minutes later seemed to have set them back on course as they dominated the opening half but the Bundesliga side, bold and enterprising, held on until David Silva cashed in on a late defensive error.
It was United's fourth successive winless outing following a 3-1 Premier League defeat by West Ham on Saturday, which came on the back of a 1-1 home draw with Wolverhampton and League Cup elimination by second-tier Derby County.
In Group E, fullback Noussair Mazraoui earned a youthful Ajax side a 1-1 draw at misfiring Bayern Munich at the Allianz Arena.
"We must keep trying to score", he said.
"The difficulties we might face [with injuries] we will resolve with the resources we have", Lopetegui said.
Madrid sits atop Group G after a convincing 3-0 win over AS Roma in their first game of the tournament, while Moscow is tied in second place after a draw with Viktoria Plzen.
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